Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of intracellular signaling adaptors that associate with the cytoplasmic tails diverse range lymphocyte receptors, including members TNFR superfamily, Toll-like (TLR)/interleukin-1 (IL-1) and IL-6 major targets for therapeutic intervention inflammatory diseases. TRAF5 is one seven TRAF highly expressed by B- T-lymphocytes. As compared to other members, biological pathophysiological functions have remained ambiguous since its discovery. promotes molecules such as glucocorticoid-induced family-related protein (GITR), CD27, CD40. In contrast, limits activity common subunit glycoprotein 130 kDa (gp130) in CD4+ T cells requires IL-27. also restrains TLR B cells. Thus, regulates both positive negative ways. This review will summarize findings recent studies terms how lymphocytes cell types expression contributes autoimmune diseases mice humans.