Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs
نویسندگان
چکیده
منابع مشابه
Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs
Ronin (THAP11), a DNA-binding protein that evolved from a primordial DNA transposon by molecular domestication, recognizes a hyperconserved promoter sequence to control developmentally and metabolically essential genes in pluripotent stem cells. However, it remains unclear whether Ronin or related THAP proteins perform similar functions in development. Here, we present evidence that Ronin funct...
متن کاملModifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture
Transcriptional activation of the IFN-beta gene in response to virus infection requires the assembly of an enhanceosome, which instructs a recruitment program of chromatin modifiers/remodelers and general transcription factors to the promoter. This program culminates with sliding of a nucleosome blocking the core promoter to a downstream position, a prerequisite for transcriptional activation. ...
متن کاملP-157: Polymorphic Core Promoter GA-repeats Alter Gene Expression of The Early Embryonic Developmental Genes
Background: We examine the GA-repeat core promoters of MECOM and GABRA3 in human embryonic kidney-293 cell line and show that those GA-repeats have promoter activity,and those different alleles of the repeats can significantly alter gene expression.We propose a novel role for GA-repeat core promoters to regulate gene expression in the genes involved in development and evolution. Materials and M...
متن کاملExpression of growth hormone gene during early development of Siberian sturgeon (Acipenser baerii)
The mRNA expression of growth hormone (GH) gene in early development stages of Siberian sturgeon was investigated using RT-PCR method. Samples were collected from unfertilized eggs up to 50 days post hatched (dph) larvae in 11 different times. Ribosomal protein L6 (RPL6) transcripts were used as the internal standard during quantification of GH mRNA expression. The results showed that the GH mR...
متن کاملPrevention of Heart Disease by Controlling Risk Factors
For a long period of time some different hypothesis have been published about arteriosclerosis but none of them has discovered the pathogenesis and effective treatment of this entity. By elemination of risk factors it is not clear that the disease process stops or reverses. Preventiona and treatment of risk factors should start before manifestation of arteriosclerosis sympthoms. The result of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.10.036