Rotavirus vaccines and intussusception: A little alarm bell perhaps?
نویسندگان
چکیده
منابع مشابه
Intussusception, rotavirus, and oral vaccines: summary of a workshop.
Rotavirus gastroenteritis continues to cause substantial morbidity and mortality worldwide, despite widespread breastfeeding and use of oral rehydration therapy. This burden of disease indicates that an effective, safe rotavirus vaccine is needed, and in 1998 the first rhesus-human reassortant rotavirus tetravalent vaccine, Rotashield, was licensed in the United States. However, the recommendat...
متن کاملRotavirus vaccines.
Rotavirus, the most common cause of severe diarrhea and a leading cause of mortality in children, has been a priority target for vaccine development for the past several years. The first rotavirus vaccine licensed in the United States was withdrawn because of an association of the vaccine with intussusception. However, the need for a vaccine is greatest in the developing world, because the bene...
متن کاملRotavirus vaccines
To estimate the global illness and deaths caused by rotavirus disease, we reviewed studies published from 1986 to 2000 on deaths caused by diarrhea and on rotavirus infections in children. We assessed rotavirus-associated illness in three clinical settings (mild cases requiring home care alone, moderate cases requiring a clinic visit, and severe cases requiring hospitalization) and death rates ...
متن کاملIntussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program.
BACKGROUND Estimates of the risk of intussusception (IS) associated with currently licensed rotavirus vaccines (RV1 [Rotarix; GSK] and RV5 [RotaTeq; Merck]) diverge. Contemporaneous introduction of both vaccines in Australia enabled a population-based assessment of risk. METHODS Confirmed cases of IS in infants aged 1 to <12 months were identified from national hospitalization databases, supp...
متن کامل[Post-licensure passive safety surveillance of rotavirus vaccines: reporting sensitivity for intussusception].
INTRODUCTION The aims of this study were to describe the reports of suspected adverse events due to rotavirus vaccines, and assess the reporting sensitivity for intussusception. MATERIAL AND METHODS Descriptive study performed using the reports of suspected adverse events following rotavirus vaccination in infants aged less than 10 months, as registered in the Pharmacovigilance Centre of the ...
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ژورنال
عنوان ژورنال: Sri Lanka Journal of Child Health
سال: 2014
ISSN: 2386-110X,1391-5452
DOI: 10.4038/sljch.v43i1.6654