Roux-en-Y gastric bypass potentially improved intestinal permeability by regulating gut innate immunity in diet-induced obese mice

Abstract Roux-en-Y gastric bypass (RYGB) has been demonstrated to be the most effective treatment for morbid obesity, yet impact of RYGB on intestinal permeability is not fully known. In this work, we subjected obese mice and sham operation procedures. Serum lipopolysaccharide (LPS) level, inflammatory cytokines were measured at 8 weeks post surgery. contrast surgery, reduced body weight, improved glucose tolerance insulin resistance, decreased serum levels LPS, IL6 TNF?. Intestinal common limb colon was significantly in group compared group. The mRNA IL1?, IL6, TLR4 intestine with expression islet-derived 3? (REG3?), 3? (REG3?) alkaline phosphatase (IAP) higher than conclusion, a diet-induced obesity (DIO) mouse model, both attenuated systemic inflammation after surgery associated innate immunity, which might result from enhanced production IAP antimicrobial peptides.