RP-HPLC method for estimation of miglitol and metformin hydrochloride in pharmaceutical formulation
نویسندگان
چکیده
A simple, rapid and sensitive RP-HPLC method was developed for the quantitative determination of metformin hydrochloride miglitol in combined tablet dosage form. The chromatographic analysis carried out on Phenomenex Gemini C18 (250 x 4.6 mm, 5 μm) with mobile phase containing methanol: TEA buffer (50:50 v/v). flow rate 1.0 mL/min effluents were monitored at 272 nm. retention times 2.121 min 3.643 min, respectively. proposed validated respect to linearity, accuracy, precision, specificity robustness.The found successfully applied estimation
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ژورنال
عنوان ژورنال: GSC biological and pharmaceutical sciences
سال: 2023
ISSN: ['2581-3250']
DOI: https://doi.org/10.30574/gscbps.2023.23.3.0219