S858 SUZ12 INACTIVATION COOPERATES WITH JAK3 MUTANT SIGNALING TO DRIVE T-ALL DEVELOPMENT
نویسندگان
چکیده
منابع مشابه
Mutant JAK3 FERMents ATLL.
Loss-of-function mutations in Janus kinase 3 (JAK3) are an underlying cause of severe combined immunodeficiency (SCID), whereas hyperactive JAK3 mutants have been identified in hematolocigal malignancies.1-3 In this issue of Blood, Elliot et al place JAK3 again under the magnifying lens and describe novel gain-of-function mutations in the FERM (Founding members: band 4.1, Ezrin, Radixin, and Mo...
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ژورنال
عنوان ژورنال: HemaSphere
سال: 2019
ISSN: 2572-9241
DOI: 10.1097/01.hs9.0000561712.29231.fb