Sample handler for x-ray tomographic microscopy and image-guided failure assessment

CEP10071 - Evaluation report: X-ray tomographic image guided radiotherapy systems

X-ray Tomographic Microscopy at TOMCAT

Synchrotron-based X-ray Tomographic Microscopy is a powerful technique for fast non-destructive, high resolution quantitative volumetric investigations on diverse samples. At the TOMCAT (TOmographic Microscopy and Coherent rAdiology experimenTs) beamline at the Swiss Light Source, synchrotron light is delivered by a 2.9 T superbend. The main optical component, a Double Crystal Multilayer Monoch...

Towards Sub-100 Nm X-ray Microscopy for Tomographic Applications

We have demonstrated that structures down to 150 nm can be visualized in X-ray projection images using a nano-focus X-ray source. Due to their unlimited depth of focus, they don a limit on the specimen size in the case of 3D tomographic imaging. Further simulation studies have shown that optimization of the detector response curve and switching from a reflective Xray target to a transmission ta...

Numerical model for tomographic image formation in transmission x-ray microscopy.

We present a numerical image-formation model for investigating the influence of partial coherence, sample thickness and depth-of-focus on the accuracy of tomographic reconstructions in transmission x-ray microscopes. The model combines wave propagation through the object by finite difference techniques with Fourier methods. We include a ray-tracing model to analyse the origin of detrimental str...

Image formation in cellular X-ray microscopy.

Soft X-ray Tomographic (TomoX) microscopy has become a reality in the last years. The resolution range of this technique nicely fits between confocal and electron microscopies and will play a key role in the elucidation of the organization between the molecular and the organelle levels. In fact, it offers the possibility of imaging three-dimensional structures of hydrated biological specimens n...