Sample Size Calculation in Clinical Trials
نویسندگان
چکیده
منابع مشابه
sample size calculation of clinical trials published in two leading endodontic journals
introduction: the purpose of this article was to evaluate the quality of sample size calculation reports in published clinical trials in journal of endodontics and international endodontic journal in years 2000-1 and 2009-10. materials and methods: articles fulfilling the inclusion criteria were collected. the criteria were: publication year, research design, types of control group, reporting s...
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In this paper we introduce a stochastic optimization method based ona mixed Bayesian/frequentist approach to a sample size determinationproblem in a clinical trial. The data are assumed to come from a nor-mal distribution for which both the mean and the variance are unknown.In contrast to the usual Bayesian decision theoretic methodology, whichassumes a single decision maker, our method recogni...
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An outcome variable is one which we hope to change, predict or estimate in a trial. Examples: • Systolic blood pressure in a hypertension trial • Caesarean section rate in an obstetric trial • Survival time in a cancer trial How many outcome variables should I have? If we have many outcome variables: • all possibilities would be covered, • we would be less likely to miss something, • the risk o...
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OBJECTIVES To assess quality of reporting of sample size calculation, ascertain accuracy of calculations, and determine the relevance of assumptions made when calculating sample size in randomised controlled trials. DESIGN Review. DATA SOURCES We searched MEDLINE for all primary reports of two arm parallel group randomised controlled trials of superiority with a single primary outcome publi...
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Adaptive clinical trials are becoming very popular because of their flexibility in allowing mid-stream changes of sample size, endpoints, populations, etc. At the same time, they have been regarded with mistrust because they can produce bizarre results in very extreme settings. Understanding the advantages and disadvantages of these rapidly developing methods is a must. This paper reviews flexi...
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ژورنال
عنوان ژورنال: Deutsches Aerzteblatt Online
سال: 2010
ISSN: 1866-0452
DOI: 10.3238/arztebl.2010.0552