SaO010TRANSCRIPTOMIC EFFECTS OF PERITONEAL DIALYSIS FLUID SUPPLEMENTATION WITH ALANYL-GLUTAMINE DIPEPTIDE SUGGEST PERTONEAL IMMUNOMODULATION IN A PILOT CLINICAL TRIAL
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چکیده
منابع مشابه
Addition of Alanyl-Glutamine to Dialysis Fluid Restores Peritoneal Cellular Stress Responses – A First-In-Man Trial
BACKGROUND Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate peritoneal injury associated with PD fluid exposure, potentially due to peritoneal glutamine depletion. In this randomized cross-over phase I/II trial we investigated cytoprotective effects of alanyl-glutamine (AlaGln) addition to...
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Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guide the management of PD patients, little is known about the potential of PDE to define pathomechanism-associated molecular signatures in PD.We therefore subj...
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BACKGROUND Glutamine (Gln) may become conditionally indispensable during critical illness. The short-term metabolic effects of enteral versus parenteral Gln supplementation are unknown in this clinical setting. OBJECTIVES We studied metabolic effects of intravenous (i.v.) alanyl-Gln dipeptide (AG) supplementation and enteral (e.n.) AG supplementation on plasma Gln concentration, antioxidant s...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2015
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfv147.02