Scouting the receptor-binding domain of SARS coronavirus 2: a comprehensive immunoinformatics inquisition
نویسندگان
چکیده
منابع مشابه
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.
The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-termina...
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Background and purpose: In 2019, the world has witnessed the emergence of a virus that caused acute respiratory distress syndrome in human with high mortality rates (approximately 3.7%). So far, no effective treatment has been proven against COVID-19. This study aimed at designing a multi-epitope vaccine combining several T-cell and B-cell epitopes of the SARS-CoV-2. Materials and methods: Bas...
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The spike protein on the envelope of SARS-coronavirus (SARS-CoV) guides viral entry into cells by first binding to its cellular receptor and then fusing viral envelope and cellular membranes. It consists of a large ecdotomain (S-e) (residues 12~1190), a transmembrane anchor, and a short intracellular tail. S-e contains two regions, a receptorbinding region S1 and a membrane-fusion region S2. Th...
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Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, the three-dimensional structures of several of the replicase/transcriptase components of SARS coronavirus (SARS-CoV), the non-structural proteins (Nsps), have been determined. However, within the large Nsp3 (1922 amino-acid residues), the structure and function of the so-called SARS-unique domain (SUD) have remained elusive...
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ژورنال
عنوان ژورنال: Future Virology
سال: 2021
ISSN: 1746-0794,1746-0808
DOI: 10.2217/fvl-2020-0269