Screen-detected breast cancers have a lower mitotic activity index

Biologic characteristics of interval and screen-detected breast cancers.

BACKGROUND Interval breast cancer is defined as a cancer that is detected within 12 months after a negative mammogram. The failure of mammography to detect breast cancer depends on testing procedures, radiologist interpretation, patient characteristics, and tumor properties. Although errors by radiologists explain some interval cancers, another explanation is that the tumor is rapidly growing a...

Re: Biologic characteristics of interval and screen-detected breast cancers.

In their recent work, Gilliland et al. (1) have shown that interval breast cancers, defined as cancers detected within 12 months after a negative mammography, are frequently high-grade, rapidly growing, and aggressive cancers. In particular, tumor proliferation rate and p53 overexpression are independent determinants of interval breast cancers, and these characteristics are seen more often amon...

A UK analysis of all symptomatic and screen-detected breast cancers

Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers.

BACKGROUND Screening mammography is the best method to reduce mortality from breast cancer, yet some breast cancers cannot be detected by mammography. Cancers diagnosed after a negative mammogram are known as interval cancers. This study investigated whether mammographic breast density is related to the risk of interval cancer. METHODS Subjects were selected from women participating in mammog...

A basal epithelial phenotype is more frequent in interval breast cancers compared with screen detected tumors.

Interval breast cancer reduce the effectiveness of mammography screening programs. We studied 95 interval cancers, diagnosed during 1996 to 2001 as part of the population-based Norwegian Breast Cancer Screening Program. These cases were matched on size (+/-2.0 mm) to 95 screen-detected breast cancers, and the tumors were compared by immunohistochemical methods using tissue microarrays. Patients...