Search for polymorphic variants of candidate genes contributing to individual radiosensitivity

Background. Cytogenetic damage (СD) in lymphocytes induced by low doses (up to 0.1 Sv) of ionizing radiation (IR) is the main cytogenetic sign individual radiosensitivity human body. In addition DNA repair and cell death, which affect formation СD its elimination, IR effects on can be manifested through changes proliferation cells with unrepaired damage. The system cyclins cyclin-dependent kinases (CDK), provide coordination mitotic events during passage a cycle, plays crucial role regulation proliferation. Aim. To evaluate relationship single-nucleotide polymorphisms (SNPs) cycle genes an increased frequency workers nuclear power plant affected chronic occupational exposure dose range 100–500 mSv. Materials methods. object study was blood 55 conditionally healthy Siberian Chemical Plant (SCP) who were (gamma radiation) A standard analysis performed for all examined individuals. Genomic isolated from using QIAamp Blood Mini Kit (QIAGEN, Germany). genotyped 257 SNPs cyclin neighboring intergenic regions microarrays high-density CytoScan HD Array (Affymetrix, USA). Results. Taking into account Bonferroni correction, only statistically significant associations dicentric chromosomes found; other types chromosomal aberrations did not show statistical significance. rs803054 CCNI2 associated arising under influence exposure. Conclusion. discovered SNP (rs803054), whose recessive genotype SCP exposed at mSv over long time, considered as potential marker radiosensitivity. confirm identified associations, further validation studies are needed expanded sample people