Secondary Signal Change and an Apparent Diffusion Coefficient Decrease of the Substantia Nigra After Striatal Infarction

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Secondary signal change and an apparent diffusion coefficient decrease of the substantia nigra after striatal infarction.

BACKGROUND AND PURPOSE Diffusion-weighted imaging can depict secondary signal change of the substantia nigra of patients with ipsilateral striatal infarction via a decrease in the apparent diffusion coefficient (ADC). Clinical predictors of this phenomenon remain unclear. METHODS We assessed 98 stroke patients with acute ischemic lesions in the hemilateral basal ganglia, external capsule, or ...

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Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction

A 74-year-old woman was admitted due to a 4-day history of disorientation. Although her symptoms showed improvement, brain magnetic resonance imaging (MRI) (Day 3) revealed a high-intensity lesion in the right basal ganglia in diffusion-weighted images and T2WI without any changes on magnetic resonance angiography (Picture 1), which supported a diagnosis of striatal infarction, presumably due t...

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Focal ischemia may induce pathological alterations in brain areas distant from the primary lesion. In animal models, exofocal neuron death in the ipsilateral midbrain has been described after occlusion of the middle cerebral artery (MCA). Using sequential magnetic resonance imaging (T2- and diffusion-weighted) at 3 Tesla, we investigated acute ischemic stroke patients on days 1, 2, 6, 8, and 10...

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Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke.

Diffusion-weighted MRI (DWI) is a sensitive and reliable marker of cerebral ischemia. Within minutes of an ischemic event in the brain, the microscopic motion of water molecules measured with DWI, termed the apparent diffusion coefficient (ADC), decreases within the infarcted region. However, although the change is related to cell swelling, the precise pathological mechanism remains elusive. We...

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ژورنال

عنوان ژورنال: Stroke

سال: 2013

ISSN: 0039-2499,1524-4628

DOI: 10.1161/strokeaha.112.673020