Segmental Duplications: What's Missing, Misassigned, and Misassembled---and Should We Care?
نویسندگان
چکیده
منابع مشابه
Comparing genomes with rearrangements and segmental duplications
MOTIVATION Large-scale evolutionary events such as genomic rearrange.ments and segmental duplications form an important part of the evolution of genomes and are widely studied from both biological and computational perspectives. A basic computational problem is to infer these events in the evolutionary history for given modern genomes, a task for which many algorithms have been proposed under v...
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Of the corrections employed for quantitative electron microprobe analysis, the correction for effects of fluorescence by characteristic x-ray lines has changed the least since the early re-parameterization of Castaing’s original correction by S.J.B. Reed in 1965 [1], and formal correction for the effects of continuum fluorescence is still seldom applied with no consensus parameterization employ...
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Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common disease. Analyses of primate genomes have shown an increase in the proportion of interspersed segmental duplications within the genomes of humans and great apes. This is in contrast to other mammalian genomes that appear to have their recently dup...
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متن کاملRecent segmental duplications in the human genome.
Primate-specific segmental duplications are considered important in human disease and evolution. The inability to distinguish between allelic and duplication sequence overlap has hampered their characterization as well as assembly and annotation of our genome. We developed a method whereby each public sequence is analyzed at the clone level for overrepresentation within a whole-genome shotgun s...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2001
ISSN: 1088-9051
DOI: 10.1101/gr.188901