Selective Inhibition of Extracellular Thioredoxin by Asymmetric Disulfides
نویسندگان
چکیده
منابع مشابه
Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1
The thiol-disulfide oxidoreductase thioredoxin-1 (Trx1) is known to be secreted by leukocytes and to exhibit cytokine-like properties. Extracellular effects of Trx1 require a functional active site, suggesting a redox-based mechanism of action. However, specific cell surface proteins and pathways coupling extracellular Trx1 redox activity to cellular responses have not been identified so far. U...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2013
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm301775s