Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide
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منابع مشابه
in vitro analysis of csa-induced hepatotoxicity in hepg2 cell line: oxidative stress and α2 and β1 integrin subunits expression
background cyclosporine a (csa)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of csa itself or from reactive oxygen species (ros) overproduction. objectives in this study we aimed to identify the cellular mechanisms underlying csa-induced hepatic injury by investigating the activation patterns of the antioxidant enzymes,...
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Ultra-small glycan-passivated gold nanoparticles of <2nm diameter were funtionalised with a short HS-EG(8)-COOH ligand. The nanoparticles were subsequently labelled, in a stoichiometrically controllable manner, with integrin-binding peptide SIKVAV and the maytansinoid cytotoxin DM4. In vitro assays showed significantly increased integrinmediated uptake of SIKVAV labelled nanoparticles in HepG2 ...
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ژورنال
عنوان ژورنال: Molecules
سال: 2020
ISSN: 1420-3049
DOI: 10.3390/molecules25184298