Semaphorin 3A potentiates the profibrotic effects of transforming growth factor-β1 in the cornea
نویسندگان
چکیده
منابع مشابه
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Semaphorin 3A blocks the formation of pathologic choroidal neovascularization induced by transforming growth factor beta
OBJECTIVE Choroidal neovascularization (CNV) is a major cause of vision loss in retinal diseases such as age-related macular degeneration (AMD). Previously, we demonstrated that semaphorin3A (Sema3A), which is a chemorepellent guidance molecule, inhibited the formation of retina neovascularization. In the present study, we investigated the antiangiogenic effects of Sema3A on transforming growth...
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15 صفحه اولTransforming growth factor-β1 in plaque morphea
INTRODUCTION Morphea (localized scleroderma) is a rare cutaneous disease characterized by skin fibrosis of unknown pathogenesis. Transforming growth factor-β (TGF-β) is a potent profibrotic factor. The role of TGF-β in morphea remains unclear. AIM The goal of this study was to estimate the expression level of TGF-β1 in skin and peripheral blood mononuclear cells as well as the plasma levels o...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2020
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2019.10.107