Sequential Development

Sequential Testing in Product Development

A fundamental problem in managing product development is the optimal timing, frequency, and fidelity of sequential testing activities that are carried out to evaluate novel product concepts and designs. In this paper, we develop a mathematical model that treats testing as an activity that generates information about technical and customer-need related problems. An analysis of the model results ...

Effect of EGF on development of bovine embryo cultured in G1/G2 sequential media

The nutritional requirements of mammalian embryos changes throughout pre-implantation period, coincident with changes in the secretion of the female reproductive tract. Therefore, it has been suggested that sequential culture media may support nutritional requirements for optimal growth of the mammalian embryos. In this study, we investigated the effect of two different concentrations (10 or 10...

LGR4 is required for sequential molar development

Tooth development requires proliferation, differentiation, and specific migration of dental epithelial cells, through well-organized signaling interactions with mesenchymal cells. Recently, it has been reported that leucine-rich repeat-containing G protein coupled receptor 4 (LGR4), the receptor of R-spondins, is expressed in many epithelial cells in various organs and tissues and is essential ...

Sequential Methods and Their Applications

Sequential development of multiple mechanical complications of myocardial infarction.

A71-year-old man with a medical history of hypertension and chronic renal failure presented to the emergency room with chest discomfort and dyspnea for 12 hours. The findings of the ECG (Figure 1) showed acute inferolateral ST-segment elevation myocardial infarction. The first troponin-I, creatine phosphokinase, and creatine kinase (CKMB) measurements were 19.3 ng/mL, 575U/L, and 68.6 ng/mL, re...