Serotonin syndrome secondary to tramadol and citalopram

Serotonin syndrome associated with tramadol.

Tramadol Pill Alone May Cause Serotonin Syndrome

Correspondence To the Editor: Tramadol is a synthetic opioid analgesic chemically related to codeine and is classified as a Class II drug for the treatment of moderate intensity pain according to the WHO recommendation. Tramadol has low affinity for μ‑ and κ‑opioid receptors and inhibits the reuptake of both norepinephrine and serotonin (5‑hydroxytryptamine) neurotransmitters. It stimulates the...

An Unusual Case of Serotonin Syndrome with Oxycodone and Citalopram

A 77-year-old female with recurrent non-small-cell lung cancer presented to a hospital outpatient clinic with tremor, weakness, inability to coordinate motor movements, and confusion. It was suspected that the symptoms were due to possible central nervous system metastases; however, a CT scan of her head was unremarkable. The lung clinic liaison pharmacist took a medication history from the pat...

Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review.

BACKGROUND Serotonin syndrome is a mild to potentially life-threatening syndrome associated with excessive serotonergic activity within the central nervous system. Serotonin syndrome is associated with medication use, drug interactions, and overdose. While serotonin syndrome is often associated with the use of selective serotonin inhibitors (SSRI), an increasing number of reports are being pres...

Brain serotonin content regulates the manifestation of tramadol-induced seizures in rats: disparity between tramadol-induced seizure and serotonin syndrome.

BACKGROUND Tramadol-induced seizures might be pathologically associated with serotonin syndrome. Here, the authors investigated the relationship between serotonin and the seizure-inducing potential of tramadol. METHODS Two groups of rats received pretreatment to modulate brain levels of serotonin and one group was treated as a sham control (n = 6 per group). Serotonin modulation groups receiv...