Serotonin Syndrome with Perioperative Oxycodone and Pregabalin

Serotonin syndrome with perioperative oxycodone and pregabalin.

An Unusual Case of Serotonin Syndrome with Oxycodone and Citalopram

A 77-year-old female with recurrent non-small-cell lung cancer presented to a hospital outpatient clinic with tremor, weakness, inability to coordinate motor movements, and confusion. It was suspected that the symptoms were due to possible central nervous system metastases; however, a CT scan of her head was unremarkable. The lung clinic liaison pharmacist took a medication history from the pat...

Serotonin syndrome after initiation of pregabalin on a stable regimen of antidepressant medication

Aims: Serotonin syndrome is a potentially life-threatening drug interaction caused by excess serotonin concentration in the central nervous system and/or peripheral nervous system leading to cognitive, autonomic and somatic effects ranging from barely perceptible to fatal. A number of drugs and drug interactions cause serotonin syndrome, however, the exact mechanisms often remain elusive. Prese...

A protocol for a systematic review for perioperative pregabalin use

BACKGROUND Perioperative pain management has recently been revolutionized with the recognition of novel mechanisms and introduction of newer drugs. Many randomized trials have studied the use of the gabapentinoid anti-epileptic, pregabalin, in acute pain. Published systematic reviews suggest that using pregabalin for perioperative pain management may decrease analgesic requirements and pain sco...

Perioperative Pregabalin for Postoperative Pain Relief after Thoracotomy

Background: Pregabalin is efective both at controlling postoperative pain and preventing chronic neuropathic pain. Local anaesthetic iniltration is a simple and inexpensive method to provide postoperative analgesia. In this study we tested the hypothesis that pregabalin administered perioperatively combined with continuous wound infusion will aid better the post-thoracotomy pain management comp...