Serpins: the uncut version
نویسندگان
چکیده
منابع مشابه
Hyman Leben Word prosody II Tone Systems Full Uncut Version
All languages use “tone” if what is meant is either pitch or the F0 variations that are unavoidable in spoken language. However, this is not what is generally meant when the term is used by phonologists. Instead, there is a major typological split between those languages that use tone to distinguish morphemes and words vs. those that do not. Found in large numbers of languages in Sub-Saharan Af...
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Members of the serpin (serine proteinase inhibitor) superfamily have been identified in higher multicellular eukaryotes (plants and animals) and viruses but not in bacteria, archaea, or fungi. Thus, the ancestral serpin and the origin of the serpin inhibitory mechanism remain obscure. In this study we characterize 12 serpin-like sequences in the genomes of prokaryotic organisms, extending this ...
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Fig. 1. Representative crystal structures of members of the serpin family. Cartoon diagrams were produced using MOLSCRIPT (21): A. bovine trypsin proteinase inhibitor, pdb accession 1BPI B. cleaved antitrypsin, 7API C. inact ovalbumin, 1OVA D. inact antitrypsin, 1QLP E. docking complex between inactive trypsin and serpin 1K, 1I99 F. covalent complex between trypsin and antitrypsin, 1EZX G. late...
متن کاملEvolutionary history of the uterine serpins.
A bioinformatics analysis was conducted on the four members of the uterine serpin (US) family of serpins. Evolutionary analysis of the protein sequences and 86 homologous serpins by maximum parsimony and distance methods indicated that the uterine serpins proteins form a clade distinct from other serpins. Ancestral sequences were reconstructed throughout the evolutionary tree by parsimony. Thes...
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The inhibition of activated protein C by six different serine protease inhibitors (serpins) that have arginine residues in the P1 position has been investigated. Micromolar concentrations of C1-inhibitor failed to inhibit the enzyme, and it was inhibited only slowly by antithrombin III with an association rate constant (kass.) of 0.15 M-1.s-1. The kass. values for the other serpins tested (prot...
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ژورنال
عنوان ژورنال: Structure
سال: 1994
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(00)00025-3