Serum amyloid A, an acute phase protein, stimulates proliferative and proinflammatory responses of keratinocytes
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چکیده
منابع مشابه
The acute phase protein serum amyloid A primes neutrophils.
We studied here the effect of the acute phase protein serum amyloid A (SAA) on the oxidative burst of neutrophils. Incubation of neutrophils with SAA increased the rate of oxygen uptake and the production of reactive oxygen species of neutrophils activated with opsonized zymosan (OZ). The increment in the neutrophil oxidative burst was dependent on SAA concentration in the range of 3-33 microg ...
متن کاملAcute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties
OBJECTIVE To determine if serum amyloid A (A-SAA) could be detected in human osteoarthritic (OA) joints and further clarify if high A-SAA level in joints result from a local production or from a diffusion process from abnormally elevated plasma concentration. Regulatory mechanism of A-SAA expression and its pro-inflammatory properties were also investigated. METHODS A-SAA levels in serum and ...
متن کاملAcute-phase response protein serum amyloid A stimulates renal tubule formation: studies in vitro and in vivo.
Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acute-phase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule format...
متن کاملThe Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates
The distinction between exudates and transudates is very important in the patient management. Here we evaluate whether the acute-phase protein serum amyloid A (SAA), in comparison with C reactive protein (CRP) and total protein (TP), can be useful in this discrimination. CRP, SAA, and TP were determined in 36 exudate samples (27 pleural and 9 ascitic) and in 12 transudates (9 pleural and 3 asci...
متن کاملsurvey on relationship between acute phase proteins (serum amyloid a, milk amyloid a and serum haptoglobin) in inflammatory diseases of dairy cattle
the objective of this study was to evaluate the concentration of these acute phase proteins(serum amyloid a, milk amyloid a and serum haptoglobin) and alteration in hematological values in some inflammatory diseases in dairy cattle. fifty-six holstein dairy cows with some inflammatory diseases were used in this study including: subclinical mastitis, hematological infections (theileriosis and an...
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ژورنال
عنوان ژورنال: Cell Proliferation
سال: 2016
ISSN: 0960-7722
DOI: 10.1111/cpr.12320