Serum level of transforming growth factor-beta1 in major idiopathic interstitial pneumonia
نویسندگان
چکیده
منابع مشابه
The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.
All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs). The LAP region of TGF-beta1 was expressed in a baculovirus expression system and purified to ho...
متن کامل[Quantifying plasma levels of transforming growth factor beta1 in idiopathic pulmonary fibrosis].
OBJECTIVE Transforming growth factor ss1 (TGF-ss1) is one of the key profibrotic mediators in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The purpose of this study was to investigate the prognostic value of quantifying TGF-ss1 levels in patients with IPF. PATIENTS AND METHODS We conducted a prospective study of 29 IPF patients and 27 healthy controls. Enzyme-linked immunosorbent ...
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Although autoantibodies are routinely screened in patients with idiopathic interstitial pneumonia, there are no reliable data on their clinical usefulness. The aim of this study was to investigate the prognostic value of autoantibodies for predicting the development of new connective tissue disease in these patients and also mortality. We conducted retrospective analysis of the baseline, and fo...
متن کاملIdiopathic Interstitial Pneumonia
Division of Pulmonary and Critical Care Medicine and Department of Radiology, University of Michigan Health System, and Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan; University of California, San Francisco, San Francisco, California; University of Washington, Seattle, Washington; Mayo Clinic, Scottsdale, Arizona; and Armed Forces Institute of ...
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BACKGROUND AND PURPOSE Both vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) are expressed in higher than normal concentrations in the penumbra of patients after ischemic stroke. Because both cytokines are central to the processes of angiogenesis, tissue inflammation, and fibrosis, we performed serial measurements of these cytokines in patients with cer...
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ژورنال
عنوان ژورنال: The Egyptian Journal of Bronchology
سال: 2020
ISSN: 1687-8426,2314-8551
DOI: 10.1186/s43168-020-00023-0