Serum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis
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منابع مشابه
Serum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis
BACKGROUND COMP (Cartilage oligomeric matrix protein) is a matrix protein, which is currently studied as a potential serum marker for cartilage processes in osteoarthritis (OA). The influence of physical exercise on serum COMP is not fully elucidated. The objective of the present study was to monitor serum levels of COMP during a randomised controlled trial of physical exercise vs. standardised...
متن کاملCartilage Oligomeric Matrix Protein (COMP) and Hyaluronic Acid (HA): Diagnostic Biomarkers of Knee Osteoarthritis
Osteoarthritis (OA), leads to considerable morbidity and disability in elderly [1]. The condition is diagnosed basically on clinical presentation and radiographic findings. By the time changes are visible on radiographs the disease is fairly advanced. Radiographic changes are apparent only after a year or two, but changes in biomarker levels are apparent within a few months [2]. Biomarkers are ...
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Changes in serum cartilage oligomeric matrix protein (COMP) were studied during a 6-month period from initiation of treatment of rheumatoid arthritis patients with either infliximab or etanercept, to elucidate whether the favourable results of tissue protection reported in clinical trials are corroborated by changing levels of circulating COMP. Rheumatoid arthritis patients commencing treatment...
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BACKGROUND The roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP, COMP, and the incidence/progression of KOA. METHODS A systematic search was conducted on PubMed and Embase until September, 2016 for all the relevant studies. The pooled mean...
متن کاملSerum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis.
OBJECTIVE To be used in diagnostic studies, it must be demonstrated that biomarkers can differentiate between diseased and non-diseased patients. Therefore, the purpose of this study was to answer the following questions: (1) Is serum cartilage oligomeric matrix protein (sCOMP) elevated in patients with radiographically diagnosed knee osteoarthritis (OA) compared to controls? (2) Are there diff...
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ژورنال
عنوان ژورنال: BMC Musculoskeletal Disorders
سال: 2006
ISSN: 1471-2474
DOI: 10.1186/1471-2474-7-98