Shifting Paradigm of Association Studies: Value of Rare Single-Nucleotide Polymorphisms
نویسندگان
چکیده
منابع مشابه
Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms.
Currently, single-nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) of >5% are preferentially used in case-control association studies of common human diseases. Recent technological developments enable inexpensive and accurate genotyping of a large number of SNPs in thousands of cases and controls, which can provide adequate statistical power to analyze SNPs with MAF <5%. Our pu...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2008
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2007.09.006