Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation

Wet Granulation Process via Foams and Drops

Wet granulation using foaming binder solution is a new approach of liquid delivery to create granules. This study compares wet granulation via foamed binder addition method and sprayed binder addition method by studying the kinetics of foam and drop penetrations into loosely packed powder beds. Foam and drop nucleation kinetics were compared by examining specific penetration time (penetration t...

Flexible Multipurpose Continuous Processing of Pharmaceutical Tablet Manufacturing Process

Manufacturing Process Modeling and Simulation

This paper presents a methodology to be employed in the whole process design phase including first and second processing. This methodology consists of a set of steps which are characterised by an independent model. This paper’s objective is to analyse the coherence between the different models and the coherence between the model and the objectives of each step. The final stage is to develop the...

Formulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...

A Statistical Approach Towards Development and Optimization of Conventional Immediate Release Tablet of Nimorazole by Wet Granulation Technique

Till date, most of the drugs have been given in conventional immediate release dosage form. Nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. Hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...