Simulation Of Signal Transduction In Model Multiprotein Systems

Simulation of signal transduction pathways

Signal transduction is about how molecular mechanisms in cells are used to receive, process and respond to signals from outside and inside of the cell. The term signal is defined in a dual way in this context: being the molecular state of a molecule, e.g. a protein, and at the same time an abstract logical state (active/inactive). This thesis focuses on intracellular signalling: i.e. receiving ...

Complexity in ‘2-component’ signal transduction systems

The prototypical (Class I) sensory histidine kinase is comprised of a ligand binding domain coupled to an autokinase domain (Figure 1A). Ligand binding causes activation of the catalytic autokinase domain which hydrolyses ATP and autophosphorylates a conserved histidine residue located in a sub-domain of the histidine kinase. Transfer of this high energy phosphoryl group to a conserved aspartat...

Two-component systems in plant signal transduction.

In plants, two-component systems play important roles in signal transduction in response to environmental stimuli and growth regulators. Genetic and biochemical analyses indicate that sensory hybrid-type histidine kinases, ETR1 and its homologs, function as ethylene receptors and negative regulators in ethylene signaling. Two other hybrid-type histidine kinases, CKI1 and ATHK1, are implicated i...

Systems biological analyses of intracellular signal transduction

Modeling and simulation in signal transduction pathways: a systems biology approach.

Modeling, the heart of systems biology, of complex processes (example: signal transduction) is a wide scientific discipline where many approaches from different areas are confronted with the aim of better understanding, identifying and modeling of complex data coming from various sources. The purpose of this paper is to introduce the basic steps of systems biology view towards signaling pathway...