Single‐cell zeroth‐order protein degradation enhances the robustness of synthetic oscillator
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چکیده
منابع مشابه
Single-cell zeroth-order protein degradation enhances the robustness of synthetic oscillator
In Escherichia coli, protein degradation in synthetic circuits is commonly achieved by the ssrA-tagged degradation system. In this work, we show that the degradation kinetics for the green fluorescent protein fused with the native ssrA tag in each cell exhibits the zeroth-order limit of the Michaelis-Menten kinetics, rather than the commonly assumed first-order. When measured in a population, t...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2007
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100172