Site-directed mutagenesis defines a domain in the gonadotropin alpha-subunit required for assembly with the chorionic gonadotropin beta-subunit.
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چکیده
منابع مشابه
The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.
The amino acid sequences of both the alpha and beta subunits of human chorionic gonadotropin have been determined. The amino acid sequence of the alpha subunit is: Ala - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys-10 - Thr - Leu - Gln - Asp - Pro - Phe - Ser - Gln-20 - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly-30 - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro-40 -...
متن کاملSite-specific processing of the N-linked oligosaccharides of the human chorionic gonadotropin alpha subunit.
Two forms of the gonadotropin alpha subunit are synthesized in placenta and in human chorionic gonadotropin (hCG)-producing tumors: an uncombined (monomer) form and a combined (dimer) form. These forms show differences in their migration on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The slower migration of the monomeric form on sodium dodecyl sulfate-polyacrylamide gel electroph...
متن کاملThe biological and clinical significance of nicks in human chorionic gonadotropin and its free beta-subunit.
Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of two dissimilar subunits, alpha and beta. Nicks or missing peptide linkages have been found in the beta 44-52 region of the beta-subunit of hCG, whether from pregnancy or trophoblast disease. This article reviews recent reports about the location of nicks in hCG, their origin and occurrence, their effects on the steroidogen...
متن کاملEctopic production of the isolated beta subunit of human chorionic gonadotropin.
A material similar to the beta subunit of human chorionic gonadotropin (hCG-beta) was detected in serum (300 ng/ml) and tumor extract from a 75-yr-old man with pancreatic adenosquamous carcinoma. This material was indistinguishable from hCG-beta in three different types of radioimmunoassay that displayed widely varying reactions with glycoprotein trophic hormones and their subunits. In gel chro...
متن کامل[Metastatic tumor of spermatic cord with elevation of serum human chorionic gonadotropin beta-subunit].
A 62-year-old man was presented with a firm mass in right scrotum. Serum LDH and AFP were within normal range, but hCG-beta was elevated (2.3 ng/ml). Under the diagnosis of right testicular tumor, he underwent right radical orchiectomy. The specimen was a spermatic cord tumor with poorly differentiated adenocarcinoma. hCG-beta was still elevated postoperatively and gastric fiber revealed adenoc...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1992
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.6.2.1569970