Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
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چکیده
منابع مشابه
Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.
Dbl-homology guanine nucleotide exchange factors (DH-GEFs) regulate actin cytoskeletal reorganization, cell adhesion, and gene transcription via activation of Rho GTPases. However, little is known about the physiological role of mammalian DH-GEFs during development. The DH-GEF family member Trio is of particular interest because it is a multifunctional protein possessing two GEF domains, as wel...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.22.12074