Sleep parameters might affect the attrition of leukocyte telomere length

Background The relationship between sleep parameters and longitudinal shortening of telomere length is unclear. This study aimed to investigate the leukocyte (LTL) over two years. Method Among participants in validation cohort Korea Brain Aging Study for Early Diagnosis Prediction Alzheimer’s Disease, who measured both baseline follow-up (two years later) LTL were analyzed. They dichotomized according degree attrition. Clinical characteristics, including duration, latency, Pittsburgh Sleep Quality Index (PSQI), Stanford Sleepiness Scale, Epworth Scale scores compared groups. Result A total 238 patients analyzed current study. Participants with faster had a shorter duration (P = 0.013) longer latency 0.007). components PSQI, subjective measures quality, efficiency significantly worse shortening. Multivariate logistic regression analysis showed that (odds ratio [OR] 1.015, confidence interval [CI] 1.001–1.029, P 0.029), global PSQI score (OR 1.130, CI 1.017–1.256, 0.023), shortest 5.057, 1.189–21.502; 0.028), lowest 8.598, 1.584–46.672, independently associated Conclusion Poor specifically long less than 5 hours sleep, low LTL.