Small Open Reading Frames: Beautiful Needles in the Haystack
نویسندگان
چکیده
منابع مشابه
The Needles-in-Haystack Problem
We consider a new data mining problem of detecting the members of a rare class of data, the needles, that have been hidden in a set of records, the haystack. Besides the haystack, a single instance of a needle is given. It is assumed that members of the needle class are similar according to an unknown needle characterization. The goal is to find the needle records hidden in the haystack. This p...
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supplements, as in the case of vita min a. yet, other studies suggest that the main impact of poverty extends beyond diet and cannot be addressed through improved nutrition alone. Such is the expe rience from peru, where a study by the tuberculosis research group at imperial college (london, uK) has been evaluat ing whether dietary supplementation with vitamin a, vitamin D and zinc reduces t...
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Current ’classical’ algorithms recognizing protein coding sequences do not work effectively with sequences of small length. To deal with this problem we have proposed some improvements of the existing gene finders without any assumed arbitrary threshold. Introduced parameters describe position of tested sequences in the ranking of all small Open Reading Frames and short protein coding genes fou...
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Evidence is accumulating that small open reading frames (sORF, <100 codons) play key roles in many important biological processes. Yet, they are generally ignored in gene annotation despite they are far more abundant than the genes with more than 100 codons. Here, we demonstrate that popular homolog search and codon-index techniques perform poorly for small genes relative to that for larger gen...
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2. Hille, B. Ion Channels of Excitable Membranes 3rd edn., 131–160 (Sinauer, Sunderland, Massachusetts, 2001). 3. Shi, G. et al. Neuron 16, 843–852 (1996). 4. Accili, E.A. et al. J. Physiol. (Lond.) 512, 325–336 (1998). 5. Gu, C. et al. Science 301, 646–649 (2003). 6. Rettig, J. et al. Nature 369, 289–294 (1994). 7. Gulbis, J.M. et al. Cell 97, 943–952 (1999). 8. Weng, J. et al. J. Biol. Chem. ...
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ژورنال
عنوان ژورنال: Genome Research
سال: 1997
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.7.8.768