Smart Lubricant Coating with Urease‐Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation

Abstract Hydrophilic lubricant coatings with antifouling properties are commercially applied to urological devices, such as ureteral stents (USs), inhibit biofilm formation and reduce the likelihood of infectious encrustation. However, their long‐term effectiveness is limited due lack active precise antibacterial activity. Herein, this work reports a hydrophilic (defined SA‐PU/PVP) coating smart urease‐responsive antibiotic release functionality, achieved by incorporating sulfanilamide‐conjugated polyurethane (SA‐PU) polymers into commercial agent containing polyvinylpyrrolidone (PVP). During initial implantation period, PVP chains rapidly absorb urine on interface, forming lubricating layer desired activities that attachment host proteins, bacteria, urate crystals over 90%. As time progresses bacteria proliferates produces urease, urease enzymatically degrades urea linkages in SA‐PU/PVP coating, actively releasing SA antibiotics demand prevent Benefiting from synergistic activities, SA‐PU/PVP‐coated US exhibits superior performance preventing encrustation porcine model 7‐week surpassing US. This strategy offers practical solution for inhibiting device‐associated complications.