SNP Calling, Genotype Calling, and Sample Allele Frequency Estimation from New-Generation Sequencing Data
نویسندگان
چکیده
منابع مشابه
SNP Calling, Genotype Calling, and Sample Allele Frequency Estimation from New-Generation Sequencing Data
We present a statistical framework for estimation and application of sample allele frequency spectra from New-Generation Sequencing (NGS) data. In this method, we first estimate the allele frequency spectrum using maximum likelihood. In contrast to previous methods, the likelihood function is calculated using a dynamic programming algorithm and numerically optimized using analytical derivatives...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0037558