Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD

Adaptive designs for clinical trials have the potential to improve the efficiency of clinical research by, for instance, seamlessly combining different stages of a clinical development programme. Adaptive seamless designs (ASD) combining phases II and III with adaptations such as treatment or subgroup selection are becoming increasingly widely used. The work required to develop application spec...

متن کامل

An R Package for Simulation Experiments Evaluating Clinical Trial Designs

This paper presents an open-source application for evaluating competing clinical trial (CT) designs using simulations. The S4 system of classes and methods is utilized. Using object-oriented programming provides extensibility through careful, clear interface specification; using R, an open-source widely-used statistical language, makes the application extendible by the people who design CTs: bi...

متن کامل

Introducing Agility in Cloud Based Software Development through ASD

Cloud based development is a challenging task for several software engineering projects, especially for those which need change along with reusability. The present scenario of cloud computing is allowing new professional models to use agile software development. The expected upcoming trend of computing is assumed to be cloud computing as it ensures a lot of payback like no principal outflow, sp...

متن کامل

Introducing elliptic, an R package for elliptic and modular functions

This paper introduces the elliptic package of R routines, for numerical calculation of elliptic and related functions. Elliptic functions furnish interesting and instructive examples of many ideas of complex analysis, and package elliptic illustrates these numerically and visually. A statistical application in fluid mechanics is presented. An earlier version of this vignette was published as Ha...

متن کامل

phylodyn: an R package for phylodynamic simulation

10 We introduce phylodyn, an R package for phylodynamic analysis based on gene 11 genealogies. The package main functionality is Bayesian nonparametric estimation of 12 effective population size fluctuations over time. Our implementation includes sev13 eral Markov chain Monte Carlo-based methods and an integrated nested Laplace 14 approximation-based approach for phylodynamic inference that hav...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Trials

سال: 2011

ISSN: 1745-6215

DOI: 10.1186/1745-6215-12-s1-a8