Solution Structure of the 2A Protease from a Common Cold Agent, Human Rhinovirus C2, Strain W12
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چکیده
منابع مشابه
Solution Structure of the 2A Protease from a Common Cold Agent, Human Rhinovirus C2, Strain W12
Human rhinovirus strains differ greatly in their virulence, and this has been correlated with the differing substrate specificity of the respective 2A protease (2Apro). Rhinoviruses use their 2Apro to cleave a spectrum of cellular proteins important to virus replication and anti-host activities. These enzymes share a chymotrypsin-like fold stabilized by a tetra-coordinated zinc ion. The catalyt...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0097198