Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin
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چکیده
منابع مشابه
Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin.
In addition to mediating sister chromatid cohesion during the cell cycle, the cohesin complex associates with CTCF and with active gene regulatory elements to form long-range interactions between its binding sites. Genome-wide chromosome conformation capture had shown that cohesin's main role in interphase genome organization is in mediating interactions within architectural chromosome compartm...
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The recruitment of cohesins to pericentric chromatin in some organisms appears to require heterochromatin associated with repetitive DNA. However, neocentromeres and budding yeast centromeres lack flanking repetitive DNA, indicating that cohesin recruitment occurs through an alternative pathway. Here, we demonstrate that all budding yeast chromosomes assemble cohesin domains that extend over 20...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2015
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.184986.114