Spatial Learning Ability of SHR and SHRSP in the Morris Water Maze
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منابع مشابه
Intrahippocampal Anisomycin Impairs Spatial Performance on the Morris Water Maze.
UNLABELLED New memories are thought to be solidified (consolidated) by de novo synthesis of proteins in the period subsequent to learning. This view stems from the observation that protein synthesis inhibitors, such as anisomycin (ANI), administered during this consolidation period cause memory impairments. However, in addition to blocking protein synthesis, intrahippocampal infusions of ANI ca...
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Mouse models of Alzheimer's Disease are essential for understanding how pathological cascades alter neural circuitry and eventually disrupt cognitive function. A key prerequisite for the use of such models, therefore, is the ability to accurately and reliably measure cognitive function. The Morris Water Maze has emerged in the field as the standard test for assessing spatial cognition. There ar...
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Mouse models have been indispensable for elucidating normal and pathological processes that influence learning and memory. A widely used method for assessing these cognitive processes in mice is the Morris water maze, a classic test for examining spatial learning and memory. However, Morris water maze studies with mice have principally been performed using adult animals, which preclude studies ...
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Methylphenidate (MPD) is the most prescribed drug for attention deficit hyperactivity disorder. Licit and illicit use also occurs during pregnancy, however the effects from this use on offspring development are unknown. To model late gestational exposure, Sprague-Dawley litters were treated with 0, 5, 10, 20, or 30mg/kg×4/day every 2h with MPD on postnatal days 11-20 (within-litter design; days...
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OBJECTIVES Animals administered lipopolysaccharide exhibit dose-related sickness behaviors (decreased food intake, weight loss, and cognitive changes). While research has demonstrated that spatial learning is impaired following a lipopolysaccharide immune challenge, the results differ depending on the methodology used to evaluate spatial learning. Additionally, few studies have evaluated the ef...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1992
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.33.578