Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity

This study was aimed at determining potential effects of apple-derived pectin on weight gain, gut microbiota, gut barrier and metabolic endotoxemia in rat models of diet-induced obesity. The rats received a standard diet (control; Chow group; n = 8) or a high-fat diet (HFD; n = 32) for eight weeks to induce obesity. The top 50th percentile of weight-gainers were selected as diet induced obese r...

Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice.

Consumption of a high-fat diet (HFD), which is associated with chronic 'low-grade' systemic inflammation, alters the gut microbiota (GM). The aim of the present study was to investigate the ability of an oleic acid-derived compound (S1) and a combination of n-3 fatty acids (EPA and DHA, S2) to modulate both body weight and the GM in HFD-induced obese mice. A total of eighty mice were fed either...

Gut Microbiota and Neuropsychiatric Disorders

Diet, Gut Microbiota and Obesity

Hongjie Li1,4* and Chuanxian Wei2,3* 1Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA 2State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, the Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China 3University of Chinese Academy of Sciences, Beijing, 100080, China 4Department of Biology, University of Rochester, River...

Responses of gut microbiota to diet composition and weight loss in lean and obese mice.

Maintenance of a reduced body weight is accompanied by a decrease in energy expenditure beyond that accounted for by reduced body mass and composition, as well as by an increased drive to eat. These effects appear to be due--in part--to reductions in circulating leptin concentrations due to loss of body fat. Gut microbiota have been implicated in the regulation of body weight. The effects of we...