Sphingomyelin-Cholesterol Complexes in Plasma Membranes
نویسندگان
چکیده
منابع مشابه
Regulation of plasma cholesterol esterification by sphingomyelin: effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity.
Although sphingomyelin (SM) is the most abundant phospholipid in the plasma, next to phosphatidylcholine (PC), its physiological function in plasma is unclear. Here we employed plasma from various genetic models of mice which naturally differ in their plasma SM/PC ratios, to study the role of SM as a modulator of LCAT, the enzyme responsible for HDL maturation and the synthesis of cholesteryl e...
متن کاملDepletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts.
This study examines the relationship between cellular sphingomyelin content and the distribution of unesterified cholesterol between the plasma-membrane pool and the putative intracellular regulatory pool. The sphingomyelin content of cultured human skin fibroblasts was reduced by treatment of intact cells with extracellularly added neutral sphingomyelinase, and subsequent changes in the activi...
متن کاملSphingomyelin of Erythrocytes Membranes is Related to Total Cholesterol and LDL-Cholesterol in Patients with Significant Coronary Arterial Disease
We quantified the main phospholipids of erythrocyte membranes and lipid profile from patients with coronary arterial disease (CAD). 202 patients between 22 and 86 years were classified in two groups: a group with CAD greater to or equal to 50% (CAD ≥ 50%) and a second group with CAD between zero and less than 50% (CAD<50%). Total phospholipids was,161.1 ± 12.0 nmol Ptotal/mg protein for patient...
متن کاملLipid raft components cholesterol and sphingomyelin increase H+/OH- permeability of phosphatidylcholine membranes.
H+/OH- permeation through lipid bilayers occurs at anomalously high rates and the determinants of proton flux through membranes are poorly understood. Since all life depends on proton gradients, it is important to develop a greater understanding of proton leak phenomena. We have used stopped-flow fluorimetry to probe the influence of two lipid raft components, chol (cholesterol) and SM (sphingo...
متن کاملRole of sphingomyelin in the regulation of cholesterol esterification in the plasma lipoproteins. Inhibition of lecithin-cholesterol acyltransferase reaction.
In order to determine whether sphingomyelin (SPH) affects the rate of cholesterol esterification by plasma lecithin-cholesterol acyltransferase (LCAT), we studied the effects of its incorporation in to defined proteoliposome substrates containing phosphatidyl choline (PC), unesterified cholesterol, and apoprotein A-I, on the activity of purified LCAT. Cholesterol esterification was inhibited by...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.3750