Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test
نویسندگان
چکیده
منابع مشابه
Spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test
BACKGROUND Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates α2-adrenergic receptor agonist binding and function, acting via the allosteric site on the α2A-adrenergic receptor. OBJECTIVES To investi...
متن کاملCorrigendum to “Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test”
[This corrects the article DOI: 10.1155/2015/902914.].
متن کاملinvolvement of spinal cb1 cannabinoid receptors on the antinociceptive effect of celecoxib in rat formalin test
results celecoxib reduced the pain behavior in both phases of the formalin test, but this antinociceptive effect was a dose-dependent manner in the late phase. rimonabant alone induced hyperalgesia as compared with the control group and pretreatment of rats with rimonabant reversed the analgesic activity of celecoxib. conclusions antinociceptive effect of celecoxib may be mediated partly throug...
متن کاملd-Methadone is antinociceptive in the rat formalin test.
The l-isomer of methadone possesses opioid activity, whereas the d-isomer is weak or inactive as an opioid. Both d- and l-methadone have been shown to bind to the N-methyl-D-aspartate (NMDA) receptor. To determine whether d-methadone has functional, in vivo NMDA receptor antagonist activity, the antinociceptive effects of d-methadone were evaluated in the rat tail-flick and formalin tests. Cumu...
متن کاملAntinociceptive drug interaction between intrathecal vitamin E and gabapentin in the rat formalin test
BACKGROUND Gabapentin is thought to exert an effect through the voltage-dependent calcium channel. Vitamin E is a widely known antioxidant which neutralizes the harmful effect of ROS which is considered to play a prominent role in various painful conditions. This study was therefore conducted to assess the antinociceptive effects of gabapentin and vitamin E and the interaction of these drugs in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pain Research and Management
سال: 2015
ISSN: 1203-6765
DOI: 10.1155/2015/902914