Squid voltage-dependent caclium channel alphal subunit and beta subunit
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چکیده
منابع مشابه
Expression, purification and crystallization of a functional core of the voltage-dependent calcium channel beta subunit.
Two versions of the functional core of the rabbit voltage-dependent calcium channel beta2a subunit were expressed in Escherichia coli. These proteins were purified to homogeneity and screened for crystallization. Crystallization conditions were refined using the hanging-drop vapour-diffusion method and two crystal forms were pursued. Crystal form I is represented by thick rods with tetragonal s...
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mational changes induced by a2d subunit coassembly. and Kevin P. Campbell The importance of the a2d subunit for Ca1 channel funcHoward Hughes Medical Institute tion is highlighted by the Caenorhabditis elegans uncDepartment of Physiology and Biophysics 36 a2d subunit mutant, which yields the same phenotype University of Iowa College of Medicine as the unc-2 a1 subunit loss of function mutant (S...
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in membrane voltage, this kind of ion channel undergoes a conformational change that opens the ion conduction pathway. The Shaker K ϩ channel from Drosophila mela-shaking phenotype of flies in which the channel gene is mutated. It is interesting that two of the early described shaking phenotypes of Drosophila, the hyperkinetic mutants , result from mutations in a K ϩ channel  subunit Summary g...
متن کاملThe voltage-dependent calcium channel beta subunit contains two stable interacting domains.
Voltage-dependent calcium channels selectively enable Ca2+ ion movement through cellular membranes. These multiprotein complexes are involved in a wide spectrum of biological processes such as signal transduction and cellular homeostasis. alpha1 is the membrane pore-forming subunit, whereas beta is an intracellular subunit that binds to alpha1, facilitating and modulating channel function. We h...
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Aminopyridines such as 4-aminopyridine (4-AP) are widely used as voltage-activated K(+) (Kv) channel blockers and can improve neuromuscular function in patients with spinal cord injury, myasthenia gravis, or multiple sclerosis. Here, we present novel evidence that 4-AP and several of its analogs directly stimulate high voltage-activated Ca(2+) channels (HVACCs) in acutely dissociated neurons. 4...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2000
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.40.s205_2