Stability of Oligopeptides in Solution. Proteolytic Digestion and Potential Dimerization Process

The specificity of peptide activity depends on the sequence amino acids and structure, so it is easy to understand great degree biodiversity that peptides can cover. Accordingly, literature shows carry out various activities, including antiproliferative, antihypertensive, antimicrobial, antioxidant, anticholesterolemic, opioid antidiabetic activities. However, potential strongly quenched by their low bioavailability. aim this work provide some insights possibility increasing bioavailability peptides. Two key points have been investigated. results demonstrate N-terminus acetylation C-terminus amidation protect from proteolytic degradation. Furthermore, be reduced formation complexes, for example through hydrophobic interactions. In particular containing cysteine dimerize with a disulfide bridge. decreasing complexes solubilizing in dissociation mixture (containing glycine, urea, dithiothreitol beta-mercaptoethanol), discussed.