Stabilization of basic fibroblast growth factor with dextran sulfate

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Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor

The radius of diffusion of basic FGF (bFGF) in the presence and in the absence of the glycosaminoglycans heparin and heparan sulfate was measured. Iodinated 125I-bFGF diffuses further in agarose, fibrin, and on a monolayer of bovine aortic endothelial (BAE) cells in the presence of heparin than in its absence. Heparan sulfates affected the diffusion of 125I-bFGF in a manner similar to, though l...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1992

ISSN: 0014-5793

DOI: 10.1016/0014-5793(92)81009-b