Stable HLA antibodies following sustained CD19+ cell depletion implicate a long-lived plasma cell source
نویسندگان
چکیده
منابع مشابه
B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.
Primary immune thrombocytopenia (ITP) is a disorder caused by autoantibody-mediated platelet destruction and decreased platelet production. Rituximab, a B cell-depleting agent, has become the first-line treatment for ITP; however, patients with refractory disease usually require splenectomy. We identified antibody-secreting cells as the major splenic B cell population that is resistant to ritux...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2020
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2020002435