Stable isotope containing peptides as probes of ligand-receptor interactions

synthesis of binuclear platinum complexes containing biphosphine ligand

هدف از این مطالعه طراحی یک روش کلی برای سنتز یک سری از کمپلکس های دو هسته ای متقارن سیکلومتاله شده پلاتین (ii) بوده که دارای یک لیگاند پل زن(1,2-bis[bis(pentafluoro-phenyl)phosphino]ethane),dfppe, است. از واکنش cis-[pt(r)2(sme2)2]، که در آنr= para-tolyl ، با یک اکی والان از لیگاند benzo[h]quinoline,bhq، در استون محصول [pt(r)(bhq)(sme2)] که در آن r= para-tolyl بدست می آید. همچنین از واکنش 5/0 اک...

The use of stable isotope tracers as metabolic probes of whole-body and limb metabolism.

We have been drawn to the use of stable isotopes rather than radioisotope tracers (Halliday & Rennie, 1982) as probes of human metabolism for a number of reasons. The most important of these are the lack of radioactive hazard, the higher sensitivity in some techniques such as measurement of tissue protein synthesis, and the ease of measurement of fractional enrichment in one instrument leading ...

Normalization Standard Consisting of 1,000 Stable Isotope Labeled Peptides

Ligand-receptor Interactions

The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic improvement of our understanding of these important phenomena. First, combination of genetic engineering and X ray cristallography made available a simultaneous...

Analysis of Receptor-Ligand Interactions.