Stalling cell division keeps leukaemia stem cells going

Cell Division: Stem Cells Take the Stage

A pool of proliferating germline stem cells is essential for gamete production in Caenorhabditis elegans. A new study applies sophisticated live imaging to assess mitotic progression and cell cycle control in these cells, yielding new insights into stem cell division.

Stem Cells So far! Stem Cell Therapy Facts and Principles

Stem cells are cells with the ability to divide for indefinite periods and to give rise to specialized cells.  Stem cell therapy has now been emerged as an extraordinary promise to treat a wide range of diseases and conditions.  However, except blood stem cell transfer by bone marrow transplant which has been used as an standard practice for more than 50 years, nearly all of therapeutic potenti...

Cancer stem cells: lessons from leukaemia.

Increasing evidence suggests that leukaemias are sustained by leukaemic stem cells. Leukaemia can indeed be viewed as aberrant haematopoietic processes initiated by rare leukaemic stem cells that have maintained or re-acquired the capacity for indefinite proliferation through accumulated mutations and/or epigenetic changes. Yet, despite their critical importance, much remains to be learned abou...

Stem cells in chronic myeloid leukaemia.

Stem cell transplantation for chronic lymphocytic leukaemia.

Early results of autologous stem cell transplantation (ASCT) in chronic lymphocytic leukaemia (CLL) suggested a significant proportion of patients remained disease-free for years, raising the possibility of cure. More recent studies have shown no evidence of a plateau in the survival curves indicating that, at best, ASCT may only prolong disease-free survival. Problems remain over progenitor ce...