Statistical methods for testing carryover effects: A mixed effects model approach
نویسندگان
چکیده
منابع مشابه
Testing for carryover effects after cessation of treatments: a design approach
BACKGROUND Recently, trials addressing noisy measurements with diagnosis occurring by exceeding thresholds (such as diabetes and hypertension) have been published which attempt to measure carryover - the impact that treatment has on an outcome after cessation. The design of these trials has been criticised and simulations have been conducted which suggest that the parallel-designs used are not ...
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We consider a variant of the usual model for crossover designs with carryover e ects. Instead of assuming that the carryover e ect of a treatment is the same regardless of the treatment in the next period, the model assumes that the carryover e ect of a treatment on itself is di erent from the carryover e ect on other treatments. For the traditional model optimal designs tend to have pairs of c...
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ژورنال
عنوان ژورنال: Contemporary Clinical Trials Communications
سال: 2021
ISSN: 2451-8654
DOI: 10.1016/j.conctc.2021.100711