Statistics for Next Generation Sequencing – Meeting Report
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چکیده
منابع مشابه
Statistics for Next Generation Sequencing – Meeting Report
AnAlysis of RnA-seq dAtA Profiling the transcriptome has been a central application of NGS technologies. Since the sequencing technology generates short reads, the first step is to map the reads onto the source genome, genes, and transcripts. Despite development of many algorithms and tools for mapping reads to the reference genomes, accurately mapping RNA-seq reads remains a tough problem due ...
متن کاملStatistical Analysis for Next Generation Sequencing----Meeting Report
The boom of next generation sequencing (NGS) technology and its applications to a wide range of biomedical fields has brought about many computational and statistical challenges. The NHGRI funded small conference “Statistical Analysis for Next Generation Sequencing” was held September 26 -27 2011 in Birmingham, AL, to discuss these statistical challenges and strategies to tackle them. A total o...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملThe Statistics of Bulk Segregant Analysis Using Next Generation Sequencing
We describe a statistical framework for QTL mapping using bulk segregant analysis (BSA) based on high throughput, short-read sequencing. Our proposed approach is based on a smoothed version of the standard G statistic, and takes into account variation in allele frequency estimates due to sampling of segregants to form bulks as well as variation introduced during the sequencing of bulks. Using s...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2012
ISSN: 1664-8021
DOI: 10.3389/fgene.2012.00128