Sterically shielded pyramidal amino groups in two 4,4′-(arylmethylene)bis(6-allyl-3-chloro-2-methylaniline) derivatives

CAS Name: 4-Chloro-2-methylbenzenamine Synonyms: 2-Amino-5-chlorotoluene; 3-chloro-6-aminotoluene; 4-chloro-2- methylaniline; 4-chloro-6-methylaniline; (4-chloro-2-methylphenyl)amine; 4-chloro-2-toluidine; 4-chloro-ortho-toluidine; 5-chloro-2-aminotoluene; para-chloro-ortho-toluidine; 2-methyl-4-chloroaniline; 2-methyl-4- chlorobenzeneamine

2-Amino-3-chloro-5-nitro­benzamide

The amide group in the title compound, C(7)H(6)ClN(3)O(3), is significantly twisted out of the plane of the benzene ring [C-C-C-O = 34.2 (5)°] whereas the nitro group is almost co-planar [O-N-C-C = 4.0 (5)°] with the ring. Intra-molecular N-H⋯O and N-H⋯Cl hydrogen bonds occur. In the crystal, the mol-ecules are linked by N-H⋯O hydrogen bonds, generating layers propagating in the ab plane.

Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity

Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was considered as a positive control drug with anticonvulsant effect [ED50 = 1.2 (0.5-1.9) mg/Kg]. Amongs...

Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity

Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was considered as a positive control drug with anticonvulsant effect [ED50 = 1.2 (0.5-1.9) mg/Kg]. Amongs...

Synthesis of Unnatural Amino Acids Functionalized with Sterically Shielded Pyrroline Nitroxides

A series of unnatural amino acids functionalized with sterically shielded pyrroline nitroxides were synthesized. Their reduction by ascorbate/glutathione indicates that L-cysteine functionalized with gem-diethylpyrroline nitroxide is reduced at the slowest rate and is comparable to that measured for the most resistant to reduction pyrroline and pyrrolidine nitroxides.